Celiac disease
OVERVIEW: What every practitioner needs to know Are you sure your patient has Celiac Disease? What are the typical findings for this disease? Celiac disease will typically present with diarrhea,...
View ArticlePrevalence of Celiac Disease High in First-Degree Relatives
HealthDay News — The prevalence of celiac disease is higher among screened first-degree relatives (FDRs) of patients with celiac disease, according to a study published online Aug. 22 in the Mayo...
View ArticleGuidelines When Performing HLA Testing for Celiac Disease
Celiac disease is caused by a combination of genetic and nongenetic factors. In celiac disease, the human leukocyte antigen (HLA) class II genes HLA-DQ2 and DQ8 are shown to be the strongest and...
View ArticleAntibody Negativity, Growth, and Metabolic Control in T1D With Celiac Disease
Approximately one-third of patients with type 1 diabetes (T1D) and celiac disease (CD) were able to achieve sustained celiac-specific antibody negativity after CD diagnosis, which was associated with...
View ArticleDoes High Gluten Intake During Childhood Increase Risk for Celiac Disease?
High gluten intake during the first 5 years of life was a statistically significant, independent risk factor for both celiac disease (CD) autoimmunity and CD in genetically predisposed children,...
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Celiac Disease: Is There a Link With Environmental Chemicals and Metals?
Celiac disease (CD), also known as gluten-sensitive enteropathy, is an autoimmune condition that involves a proinflammatory state within the small bowel that is mediated by a sensitivity to gluten.1...
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Early Introduction of Gluten Linked to Decline in Celiac Disease
HealthDay News — Introduction of gluten from age 4 months is associated with a reduced prevalence of celiac disease (CD), according to a study published online Sept. 28 in JAMA Pediatrics. Kirsty...
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IL-2 Levels Found to Be Earliest and Most Sensitive Biomarker of Acute Gluten...
Select biomarkers for celiac disease are sensitive and responsive to gluten exposure, and interleukin (IL)-2 levels were found to be the earliest and most sensitive biomarker of acute gluten exposure,...
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Celiac Disease Correlates With Increased Risk for Pancreatitis
Patients with celiac disease (CD) appear to be at increased risk for pancreatitis, especially acute pancreatitis, according to data from a retrospective study presented at the 2020 American College of...
View ArticleGluten-Free Diet Induces Changes in Intestinal Microbiota of Children With...
Adherence to a gluten-free diet (GFD) appeared to alter intestinal microbiota in children with celiac disease (CD); however, specific bacteria that served as “biomarkers” for the disease sustained,...
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New Data Support No-Biopsy Approach for Celiac Disease Diagnosis
Study data published in Gut suggest that IgA antitissue transglutaminase (tTG) titres 10 or more times the upper limit of normal (ULN) are strongly associated with small intestinal mucosal changes...
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Celiac Disease and Small Bowel Cancers: A Question of Risk
Celiac disease (CD) is an immune reaction in the small bowel that is mediated by the ingestion of gluten and leads to a proinflammatory state that affects multiple organ systems.1,2 The underlying...
View ArticleIron-Deficiency Anemia Secondary to Asymptomatic Celiac Disease: A Case Study
MR, a well-appearing 21-year-old White woman, presents to her student health clinic with a complaint of general fatigue despite being treated with iron supplementation for iron deficiency. Three years...
View ArticleType 1 Diabetes With Celiac Disease Increases Depression Risk in Adolescents
Adolescent boys and girls with type 1 diabetes (T1D) and celiac disease (CD) have an increased risk for depression, highlighting the importance of depression screenings as part of routine care,...
View ArticleTAK-101 May Prevent Gluten-Induced Immune Activation in Celiac Disease
TAK-101 was well tolerated and prevented gluten-induced immune activation in patients with celiac disease, according to a study in Gastroenterology. Investigators reported their findings regarding the...
View ArticleA Novel Endopeptidase Has Potential as an Oral Treatment for Patients With...
TAK-062, a novel, computationally designed endopeptidase by Takeda Pharmaceuticals International was found in a pharmacokinetic, safety, and tolerability phase 1 trial to be effective at rapidly...
View ArticlePotential Association Between Celiac Disease and Autism Spectrum Disorder
In a handful of high-quality studies, a potential association has been suggested between celiac disease (CD) and autism spectrum disorder (ASD), according to a study published in the Journal of...
View ArticleSeparating Fact From Fallacy in Celiac Disease
Although the conception of celiac disease has expanded, some fallacies about its clinical characteristics and management remain, according to an invited presentation by Ciaran P. Kelly, MD, at the...
View ArticleTransglutaminase 2 Inhibitor Reduces Gluten-Induced Mucosal Injury in...
A selective oral transglutaminase 2 inhibitor, dubbed ZED1227, reduced gluten-induced duodenal mucosal injury in patients with celiac disease, according to findings from the preliminary CEC-3 trial...
View ArticleRetinal Vascular Structures, Choroidal Thickness Not Linked With Celiac Disease
Retinal vasculature and subfoveal choroidal thickness do not vary significantly between children with celiac disease and their peers, according to a study published in Journal of the American...
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